| Pair Name | Cucurbitacin B, Gefitinib | ||
| Phytochemical Name | Cucurbitacin B (PubChem CID: 5281316 ) | ||
| Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cucurbitacin B, Gefitinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| In Vitro Model | PC-9 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_B260 |
| Result | CuB reduced the proliferation of GR PC9 cells by modulating the miR‑17‑5p/STAT3 axis, and may represent a promising potential novel strategy for the reversal of GR. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis. Mol Med Rep. 2021 Oct;24(4):710. doi: 10.3892/mmr.2021.12349. | Click |
